Paul Pavlidis

Profile Details

Position/Role

Principal Investigator

Affiliation

Associate Professor, Dept of Psychiatry, member of the Brain Research Centre

Website

http://www.chibi.ubc.ca/faculty/pavlidis/lab/

Phone

604 827 4157

Research Interests

My research lies at the intersection of bioinformatics and neuroscience. My current focus is on the analysis of gene expression microarray data as well as other genomics and high-throughput data using meta-analytical frameworks. The goal of this work is to improve our power to detect relationships among genes and to identify candidates for involvement in human neuropsychiatric and neurological diseases. We are developing "Gemma", a system that will permit neuroscientists to compare and combine gene expression data sets they have generated with other data sets they select from hundreds of other data sets. Gemma will also facilitate the use of other types of data including and proteomics and genetics, and neuroscience-domain-specific data such as neuroanatomy and neuropharmacology. We use methods from machine learning to mine our databases to develop hypotheses about specific genes or groups of genes. I am interested in applying and developing our ideas to other areas of neuroscience such as functional brain imaging, electrophysiological data and anatomy. I work closely with many laboratory-based neuroscience researchers to produce data and test predictions.

Selected Publications

French L, Lane S, Law T, Xu L, Pavlidis P. Application and evaluation of automated semantic annotation of gene expression experiments. Bioinformatics. 2009 Jun 15;25(12):1543-9 PubMed

Lee HK, Braynen W, Keshav K, Pavlidis P. ErmineJ: Tool for functional analysis of gene expression data sets. BMC Bioinformatics 6(1):269. (2005).PubMed

Paterlini M, Zakharenko SS, Lai WS, Qin J, Zhang H, Mukai J, Westphal KG, Olivier B, Sulzer D, Pavlidis P, Siegelbaum SA, Karayiorgou M, Gogos JA. Transcriptional and behavioral interaction between 22q11.2 orthologs modulates schizophrenia-related phenotypes in mice. Nat Neurosci 8(11):1586-94. (2005).PubMed

Barnes M, Freudenberg J, Thompson S, Aronow B, Pavlidis P. Experimental comparison and cross-validation of the Affymetrix and Illumina gene expression analysis platforms. Nucleic Acids Res 33(18):5914-23. (2005).PubMed

Erraji-Benchekroun L, Underwood MD, Arango V, Galfalvy H, Pavlidis P, Smyrniotopoulos P, Mann JJ, Sibille E. Molecular aging in human prefrontal cortex is selective and continuous throughout adult life. Biol Psychiatry 57(5):549-58. (2005).PubMed

History

Member for

1 year 32 weeks

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